Research

COMPLETED RESEARCH PROJECTS

The Partnership for Health Research Training in Kenya (P-HERT) program

The Partnership for Health Research Training in Kenya (P-HERT) is a D43 grant awarded to the University of Nairobi by the National Institutes of Health to develop and implement a Research Capacity Building Program at the University of Nairobi and Kenyatta and Maseno Universities to support Junior Faculty gain in-depth research skills and expertise in the fields of HIV/AIDS, Mental Health and Maternal Newborn & Child Health.

The Specific Aims of the proposed program follow:   

Aim 1:  To develop skills set in epidemiology, biostatistics, implementation science and responsible conduct of research during the first year of a 2-year fellowship. 

Aim 2:  Mentor trainee faculty to develop and implement a research project, disseminate study findings and use the pilot data to develop and submit a grant for funding during the final year of the 2-year fellowship

Aim 3: Foster a research environment that supports junior faculty career development by creating research training and networking opportunities for a wide range of researchers at the 4 collaborating. 

Collaborating institutions

University of Nairobi: is the premier and largest University in Kenya. UoN is the main grant recipient 

University of Washington: is a large, public flagship research university in Seattle, Washington, UW is subcontracted by the UoN in the P-HERT program

Kenyatta University: Based in Ruiru, Kiambu County. The University has a young medical school. KU is a partner in the P-HERT program

Maseno University: Maseno University is a university based in Maseno, near Kisumu, Kenya, founded in 1991 it has a young medical school as well. KU is a partner in the P-HERT program

 

LEADERSHIP

Principal Investigator - Prof Dalton Wamalwa, MPHMMed, MB.CHB is an Associate Professor of Paediatrics and Child Health at the University of Nairobi. For the past several years, he has been providing clinical care to HIV infected children and adolescents in the Kenyatta National Hospital.  He has led several research funded projects focusing on HIV infected children and adolescents, as well as a Maternal Newborn Child Health Research capacity building program. Prof Wamalwa led the NIH-funded Linked-MEPI grant on Strengthening Maternal, Newborn and Child Health research training in Kenya. He is now the PI of a recently funded D43 grant to support research training of junior faculty at the University of Nairobi in the fields of HIV, mental health and MNCH.  Prof Wamalwa has over 40 publications in peers reviewed international scientific journals.

Epidemiology Coordinator - Prof Ruth NduatiMPHMMed, MB.CHB is Professor in the Department of Paediatrics and Child health, University of Nairobi and consultant paediatrician at the Kenyatta National Hospital. Nduati has over 20 years of experience in HIV research, mentorship of both undergraduate and postgraduate students, as well as program implementation, having pioneered implementation of PMTCT in Kenya.

Biostatistics Coordinator - Dr John Kinuthia, MPHMMed, MB.CHB is the Head of Research & Programs, Kenyatta National Hospital he is a consultant Obstetrician Gynecologist, and Honorary Lecturer, Dept. of Obstetrics & Gynecology, University of Nairobi (Kenya) Dr. Kinuthia’s research has primarily focused on prevention of mother-to-child transmission of HIV. He has coordinates trainings in Implementation Science, Maternal and Neonatal Child Health and Program Management for the University of Nairobi.

Research Mentorship Lead - Dr Muthoni Mathai, PhD, MMed, MB.CHB is a Psychiatrist and senior lecturer in the Department of Psychiatry at the University of Nairobi. She teaches mentors students in research and clinical care to patients at Kenyatta National Hospital and Mathari teaching and referral hospital. Dr Mathai was the PI of the MEPI-Linked project: Research capacity building in Mental health for better health outcomes, funded by NIH/NIMH.

Short Courses Lead - Prof James MachokiMB.ChB, M.Med, FMed. Anthro, is the Director of the University of Nairobi Institute of Tropical and Infectious Diseases (UNITID, Associate Professor Department of Obstetrics and Gynecology, University of Nairobi; and Consultant Obstetrician and Gynecologist, Kenyatta National Hospital, Nairobi. Prof Machoki is the current P.I. of the UoN HIV Capacity Building Fellowship Programme. Prof Machoki is passionate about research grant writing administration capacity building, he previously lead the IEARDA grant and was in charge of the MEPI program area of research administration.

Maseno Coordinator - Prof. Wilson Odero MBBS, MSc. PhD, is an Associate Professor and Dean, School of Medicne, Maseno University. He obtained his medical degree from the Minsk Medical Institute and followed this with an MSc in Community Health from the London School of Hygiene and Tropical Medicine and a PhD in Epidemiology and Policy from the same institution. Dr. Odero has worked extensively in collaboration with organizations such as WHO and DFID on various traffic injury research and training programs. In the P-HERT program he represents and coordinates P-HERT program at Maseno University

Kenyatta University - Dr Titus Kahiga

 

TRAINEES PROFILE

Cohort 1

Mary N. Kubo, 

MB. Ch B; M. Med

Department of Clinical Medicine and Therapeutics, University of Nairobi

 

George N.  Gwako

 MB. Ch B; M. Med

Department of Obstetrics and Gynaecology, University of Nairobi

 

Beatrice Mutai

MB. Ch B; M. Med

Department Paediatrics and Child Health, University of Nairobi 

 

Ann Wanjiru Mbwayo

B.A, B Ed; MSc., PhD

Department of Psychiatry, University of Nairobi

 

George Mugendi

B. Pharm, M. Pharm,

Department of Pharmaceutics and Pharmacy Practice, University of Nairobi

 

Maurice K’ Odhiambo

B. Pharm, M. Pharm

Department of Pharmacy, Kenyatta University, Kenyatta University

 

Bernard B.O Awuonda

M. Med, MB. ChB

Department of Paediatrics and Child Health, Maseno  University 

 

Cohort two

Dr Gladys Nthambi Mwango

MMed (Diagnostic Radiology) MBChB , BSc Human Anatomy Department of Diagnostic Imaging & Radiation, UoN

 

Dr Tom Mboya Olewe

PhDc MPH, MBChB School of Public Health, UoN

 

Dr Edwin Oloo Walong

F. Anatomic Pathology, MMed (Pathology) MBChB 

Department of Pathology, UoN

 

Dr Anne Kasyoka Barasa

MMed (Pathology) MBChB Department of Human Pathology, UoN

 

Dr Lilly Adhiambo Nyamai

MMed (Ophth) MBChB Department of Ophthalmology, UoN

 

Dr Judy Wanjiru Kamau

MSc.(Child  & Adolescent Metal Health), MMed Psychiatry, MBChB Department of Psychiatry, UoN

 

Dr Lydiah Maingi-Ngunjiri

PhD, M.A, B.Ed

Department of Psychology, KU

 

Dr Amos Oyoko

MPH, MBChB 

Department of Family Medicine & Community Health, MSU

 

 

ONGOING RESEARCH PROJECTS

PROJECT TITLE: HEALTH-PROFESSIONAL EDUCATION PARTNERSHIP INITIATIVE
(HEPI) – KENYA


P.I. Prof Dalton Wamalwa, Prof Ruth Nduati
NIH GRANT NUMBER 5R25TW01121
Program Year : 2018-2023


INTRODUCTION
Health-Professional Education Partnership Initiative (HEPI) -Kenya is a grant awarded to the University of Nairobi with an objective to increase capacity for a multidisciplinary workforce to design, conduct and disseminate research to inform HIV prevention, care and treatment. The targeted workforce includes undergraduate and graduate health professional students targeted to improve practice-oriented research skills training at the collaborating Kenyan Universities and their affiliated teaching hospitals. The program also provides practice-oriented quality improvement short courses for staff at the affiliated county Hospitals.
The program has three aims.


AIM 1: Enhance HIV implementation science and dissemination research capacity in Kenya

AIM 2: Increase the pipeline of young Kenyan researchers by developing and
offering an innovative 10-week research elective that targets medicine, nursing and
pharmacy students completing clinical undergraduate (bachelors) degrees at the 4
universities.

AIM 3: Improve quality of care and evidence-based approaches at teaching hospitals by strengthening linkages between the 4 academic institutions, the Kenya MOH, and county health departments.

 

PUBLICATIONS IN 2020/2021

Gwako GN, Were F, Obimbo MM, Kinuthia J, Gachuno OW, Gichangi PB. Association between utilization and quality of antenatal care with stillbirths in four tertiary hospitals in a low-income urban setting. Acta Obstet Gynecol Scand. 2020 Jul 10. doi: 10.1111/aogs.13956.

Inwani I, Chhun N, Agot K, Cleland CM, Rao SO, Nduati R, Kinuthia J, Kurth AE. Preferred HIV Testing Modalities Among Adolescent Girls and Young Women in Kenya. J Adolesc Health. 2020 Aug 10:S1054-139X(20)30404-3. 

Wagner AD, Wilson KS, Babigumira JB, Mugo C, Mutiti PM, Neary J, Wamalwa DC, Bukusi D, John-Stewart GC, Kohler PK, Slyker JA. Can Adolescents and Young Adults in Kenya Afford Free HIV Testing Services? J Assoc Nurses AIDS Care. 2020 Jul-Aug;31(4):483-492

Njuguna IN, Wagner AD, Neary J, Omondi VO, Otieno VA, Orimba A, Mugo C, Babigumira JB, Levin C, Richardson BA, Maleche-Obimbo E, Wamalwa DC, John-Stewart G, Slyker J. Financial incentives to increase pediatric hiv testing: a randomized trial. AIDS. 2020 Oct 8. 

Karman E, Wilson KS, Mugo C, Slyker JA, Guthrie BL, Bukusi D, Inwani I, John-Stewart GC, Wamalwa D, Kohler PK. Training Exposure and Self-Rated Competence among HIV Care Providers Working with Adolescents in Kenya. J Int Assoc Provid AIDS Care. 2020 Jan-Dec

Slyker JA, Guthrie B, Pankau M, Tapia K, Wamalwa D, Benki-Nugent S, Ngugi E, Huang ML, Njuguna I, Langat A, John-Stewart G, Lehman D. Cytomegalovirus and Epstein-Barr virus viremia are associated with HIV DNA levels in the reservoir of Kenyan infants on antiretroviral therapy. J Infect Dis. 2020 Oct 

Culhane J, Sharma M, Wilson K, Roberts DA, Mugo C, Wamalwa D, Inwani I, Barnabas RV, Kohler PK. Modeling the health impact and cost threshold of long-acting ART for adolescents and young adults in Kenya. EClinicalMedicine. 2020 Jul

Akech S, Chepkirui M, Ogero M, Agweyu A, Irimu G, English M, Snow RW. The Clinical Profile of Severe Pediatric Malaria in an Area Targeted for Routine RTS,S/AS01 Malaria Vaccination in Western Kenya. Clin Infect Dis. 2020 Jul 11;71(2):372-380.

Ogero M, Akech S, Malla L, Agweyu A, Irimu G, English M; Clinical Information Network Author Group. Examining which clinicians provide admission hospital care in a high mortality setting and their adherence to guidelines: an observational study in 13 hospitals. Arch Dis Child. 2020 Jul;105(7):648-654.

Mugo C, Njuguna I, Nduati M, Omondi V, Otieno V, Nyapara F, Mabele E, Moraa H, Sherr K, Inwani I, Maleche-Obimbo E, Wamalwa D, John-Stewart G, Slyker J, Wagner AD. From research to international scale-up: stakeholder engagement essential in successful design, evaluation and implementation of paediatric HIV testing intervention. Health Policy Plan. 2020 Sep

Oliwa JN, Odero SA, Nzinga J, van Hensbroek MB, Jones C, English M, Van't Hoog A. Perspectives and practices of health workers around diagnosis of paediatric tuberculosis in hospitals in a resource-poor setting - modern diagnostics meet age-old challenges. BMC Health Serv Res. 2020 Aug 1;20(1):708. 

Aluvaala J, English M. Implementing change for facility-based peripartum care in low-income and middle-income countries. Lancet Glob Health. 2020 Aug;8(8):e980-e981

Seminario AL, Kemoli A, Benki-Nugent S, Chebet D, Gomez L, Wamalwa D, John-Stewart G, Slyker JA. Caregivers' report of HIV-associated oral manifestations among HIV-unexposed, exposed, and infected Kenyan children. Int J Paediatr Dent. 2020 Dec 25.

Slyker JA, Guthrie B, Pankau M, Tapia K, Wamalwa D, Benki-Nugent S, Ngugi E, Huang ML, Njuguna I, Langat A, John-Stewart G, Lehman D. Cytomegalovirus and Epstein-Barr virus viremia are associated with HIV DNA levels in the reservoir of Kenyan infants on antiretroviral therapy. J Infect Dis. 2020 Oct 16

Mugo C, Wang J, Begnel ER, Njuguna IN, Maleche-Obimbo E, Inwani I, Slyker JA, John-Stewart G, Wamalwa DC, Wagner AD. Home- and Clinic-Based Pediatric HIV Index Case Testing in Kenya: Uptake, HIV Prevalence, Linkage to Care, and Missed Opportunities. J Acquir Immune Defic Syndr. 2020 Dec 15

Mugo C, Njuguna I, Nduati M, Omondi V, Otieno V, Nyapara F, Mabele E, Moraa H, Sherr K, Inwani I, Maleche-Obimbo E, Wamalwa D, John-Stewart G, Slyker J, Wagner AD. From research to international scale-up: stakeholder engagement essential in successful design, evaluation and implementation of paediatric HIV testing intervention. Health Policy Plan. 2020 Nov 20;35(9):1180-1187

Njuguna IN, Beima-Sofie K, Mburu CW, Mugo C, Neary J, Itindi J, Onyango A, Richardson BA, Rubin Means A, Sharma M, Weiner BJ, Wagner AD, Oyiengo L, Wamalwa D, John-Stewart G. Adolescent transition to adult care for HIV-infected adolescents in Kenya (ATTACH): study protocol for a hybrid effectiveness-implementation cluster randomised trial. BMJ Open. 2020 Dec 2

English M, Nzinga J, Irimu G, Gathara D, Aluvaala J, McKnight J, Wong G, Molyneux S. Programme theory and linked intervention strategy for large-scale change to improve hospital care in a low and middle-income country - A Study Pre-Protocol. Wellcome Open Res. 2020 Dec 18;5:265

English M, Ogola M, Aluvaala J, Gicheha E, Irimu G, McKnight J, Vincent CA. First do no harm: practitioners' ability to 'diagnose' system weaknesses and improve safety is a critical initial step in improving care quality. Arch Dis Child. 2020 Dec 23:archdischild-2020-320630.

Gwako GN, Obimbo MM, Gichangi PB, Kinuthia J, Gachuno OW, Were F. Association between obstetric and medical risk factors and stillbirths in a low-income urban setting.Int J Gynaecol Obstet. 2020 Dec 11

English M, Strachan B, Esamai F, Ngwiri T, Warfa O, Mburugu P, Nalwa G, Gitaka J, Ngugi J, Zhao Y, Ouma P, Were F. The paediatrician workforce and its role in addressing neonatal, child and adolescent healthcare in Kenya. Arch Dis Child. 2020 Oct;105(10):927-931. doi: 10.1136/archdischild-2019-318434. Epub 2020 Jun 18.

Kariuki EW, Kuria MW, Were FN, Ndetei DM. Effectiveness of a brief psychoeducational intervention on postnatal depression in the slums, Nairobi: a longitudinal study. Arch Womens Ment Health. 2020 Nov 16

Mitchell EJ, Qureshi ZP, Were F, Daniels J, Gwako G, Osoti A, Opira J, Bradshaw L, Oliver M, Pallotti P, Ojha S. Feasibility of using an Early Warning Score for preterm or low birthweight infants in a low-resource setting: results of a mixed-methods study at a national referral hospital in Kenya. BMJ Open. 2020 Oct 28;10(10):e039061

Aluvaala J, Collins G, Maina B, Mutinda C, Waiyego M, Berkley JA, English M. Prediction modelling of inpatient neonatal mortality in high-mortality settings. Arch Dis Child. 2020 Oct 22

Oliwa JN, Nzinga J, Masini E, van Hensbroek MB, Jones C, English M, Van't Hoog A. Improving case detection of tuberculosis in hospitalised Kenyan children-employing the behaviour change wheel to aid intervention design and implementation.Implement Sci. 2020 Nov 25;15(1)

Omar AA, Nyaga G, Mungai LNW. Pseudotumor cerebri in patient on leuprolide acetate for central precocious puberty. Int J Pediatr Endocrinol. 2020 Dec 3;2020

Njuguna IN, Wagner AD, Neary J, Omondi VO, Otieno VA, Orimba A, Mugo C, Babigumira JB, Levin C, Richardson BA, Maleche-Obimbo E, Wamalwa DC, John-Stewart G, Slyker J. Financial incentives to increase pediatric HIV testing: a randomized trial. AIDS. 2021 Jan 1;35(1):125-130.

Marangu D, Zar HJ. Childhood pneumonia in Sub-Saharan Africa: Still a challenge. J Pan Afr Thorac Soc 2021;2(1):1-3. Jan 23

Neary J, Wagner AD, Omondi V, Otieno V, Mugo C, Wamalwa DC, Maleche-Obimbo E, John-Stewart GC, Slyker JA, Njuguna IN. Male caregiver barriers to HIV index-case testing of untested children. J Acquir Immune Defic Syndr. 2021 Feb 23

Maqsood R, Reus JB, Wu LI, Holland LA, Nduati R, Mbori-Ngacha D, Maleche-Obimbo E, Begnel ER, Gantt S, Ojee E, Wamalwa D, John-Stewart G, Slyker J, Lehman DA, Lim ES. Breast Milk Virome and Bacterial Microbiome Resilience in Kenyan Women Living with HIV. mSystems. 2021 Mar 16;6(2):e01079-20. 

English M, Irimu G, Akech S, Aluvaala J, Ogero M, Isaaka L, Malla L, Tuti T, Gathara D, Oliwa J, Agweyu A. Employing learning health system principles to advance research on severe neonatal and paediatric illness in Kenya.BMJ Glob Health. 2021 Mar;6(3):e005300

Minckas N, Medvedev MM, Adejuyigbe EA, Brotherton H, Chellani H, Estifanos AS, Ezeaka C, Gobezayehu AG, Irimu G, Kawaza K, Kumar V, Massawe A, Mazumder S, Mambule I, Medhanyie AA, Molyneux EM, Newton S, Salim N, Tadele H, Tann CJ, Yoshida S, Bahl R, Rao SPN, Lawn JE; COVID-19 Small and Sick Newborn Care Collaborative Group. Preterm care during the COVID-19 pandemic: A comparative risk analysis of neonatal deaths averted by kangaroo mother care versus mortality due to SARS-CoV-2 infection. EClinicalMedicine. 2021 Mar;33:100733.

Oreskovic A, Panpradist N, Marangu D, Ngwane MW, Magcaba ZP, Ngcobo S, Ngcobo Z, Horne DJ, Wilson DPK, Shapiro AE, Drain PK, Lutz BR. Diagnosing pulmonary tuberculosis using sequence-specific purification of urine cell-free DNA. J Clin Microbiol. 2021 Mar 31:JCM.00074-21. doi: 10.1128/JCM.00074-21. Epub ahead of print. PMID: 33789959.

Gwako GN, Were F, Obimbo MM, Kinuthia J, Gachuno OW, Gichangi PB..Association between utilization and quality of antenatal care with stillbirths in four tertiary hospitals in a low-income urban setting. Acta Obstet Gynecol Scand. 2021 Apr;100(4):676-683

English M, Ogola M, Aluvaala J, Gicheha E, Irimu G, McKnight J, Vincent CA. First do no harm: practitioners' ability to 'diagnose' system weaknesses and improve safety is a critical initial step in improving care quality. Arch Dis Child. 2021 Apr;106(4):326-332.